Test Code TPBF Protein Total Body Fluid
Additional Codes
Cerner |
NextGen |
Protein Total Body Fluid |
Protein Total Body Fluid |
Methodology
Colorimetric (reflectance spectrophotometry), Biuret
Patient Preparation
None
Collection Instructions
Collect specimens according to clinical policies and procedures.
Specimen Requirements
Container |
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Stability |
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Rejection Criteria |
Not Defined |
Result Reporting and Reference Values
- Reported in g/dL.
- Body fluid Total Protein is not an FDA approved assay. Reference ranges not established.
Reflex Testing
None
Limitations
- Certain drugs and clinical conditions are known to alter total protein concentration in vivo. For additional information, refer to one of the published summaries.
- Young DS. Effects of Drugs on Clinical Laboratory Tests. ed. 4. Washington D.C.: AACC Press; 1995.
- Friedman RB, Young DS. Effects of Disease on Clinical Laboratory Tests. Washington, D.C.: AACC Press; 1990.
Useful For
Serum proteins transport drugs and metabolites and maintain plasma osmotic pressure. Most serum proteins are synthesized in the liver, with the exception of gamma globulins. One of the most important serum proteins produced in the liver is albumin. Total serum protein concentration can be used for evaluation of nutritional status.
Causes of high total serum protein concentration include dehydration, Waldenström’s macroglobulinemia, multiple myeloma, hyperglobulinemia, granulomatous diseases, and some tropical diseases. Total protein concentration is occasionally increased in collagen diseases, lupus erythematosus, and other instances of chronic infection or inflammation. Causes of low total serum protein concentration include pregnancy, excessive intravenous fluid administration, cirrhosis