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Test Code TPBF Protein Total Body Fluid

Important Note

Additional Codes

Cerner

NextGen

Protein Total Body Fluid

Protein Total Body Fluid

Methodology

Colorimetric (reflectance spectrophotometry), Biuret

Patient Preparation

None

Collection Instructions

Collect specimens according to clinical policies and procedures.

Specimen Requirements

Container

 or  or  or 

Stability

Storage

Temperature

Stability

Room Temperature

18-28°C

≤ 4 hours

If separated within 4 hours

Refrigerated

2-8°C

≤ 3 days

If separated within 4 hours

Frozen

≤-18 °C

≤ 6 months

If separated within 4 hours

Rejection Criteria

Not Defined

Result Reporting and Reference Values

  • Reported in g/dL.
  • Body fluid Total Protein is not an FDA approved assay. Reference ranges not established.

Reflex Testing

None

Limitations

  • Certain drugs and clinical conditions are known to alter total protein concentration in vivo. For additional information, refer to one of the published summaries.
    • Young DS. Effects of Drugs on Clinical Laboratory Tests. ed. 4. Washington D.C.: AACC Press; 1995.
    • Friedman RB, Young DS. Effects of Disease on Clinical Laboratory Tests. Washington, D.C.: AACC Press; 1990.

Useful For

Serum proteins transport drugs and metabolites and maintain plasma osmotic pressure. Most serum proteins are synthesized in the liver, with the exception of gamma globulins. One of the most important serum proteins produced in the liver is albumin. Total serum protein concentration can be used for evaluation of nutritional status.

Causes of high total serum protein concentration include dehydration, Waldenström’s macroglobulinemia, multiple myeloma, hyperglobulinemia, granulomatous diseases, and some tropical diseases. Total protein concentration is occasionally increased in collagen diseases, lupus erythematosus, and other instances of chronic infection or inflammation. Causes of low total serum protein concentration include pregnancy, excessive intravenous fluid administration, cirrhosis