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Test Code UPRO24HR Protein Urine 24 Hour

Additional Codes

Cerner

NextGen

Protein Urine 24 Hr

Protein Urine 24 Hr

Methodology

Colorimetric (reflectance spectrophotometry) using pyrocatechol violet dye.

Patient Preparation

None

Collection Instructions

Catheterized specimens collected according to clinical policies and procedures

24 Hour Urine Collection Instructions

Specimen Requirements

Container

Stability

Storage

Temperature

Stability

Room Temperature

18–28 °C

≤ 4 hours

Refrigerated

2–8 °C

≤ 3 days

Frozen

Cannot be frozen

Cannot be frozen

Rejection Criteria

Hemolyzed or blood specimens

Result Reporting and Reference Values

Reported in mg/24hr

Age

Low

High

Critical Low

Critical High

0-18 y

N/A

149 mg/day

N/A

N/A

18 – 150y

42 mg/day

225 mg/day

N/A

N/A

Reflex Testing

None

Limitations

  • Ortho reports a bias with the following:
    • Hemoglobin at 50 mg/dL can cause a +30.64 mg/dL bias.
    • Ceftriaxone at 550 mg/dL can cause a +119.27 mg/dL bias
    • Deferoxamine mesylate at 750mg/dL can cause a +32.52 mg/dL bias
    • NaCl at 400 mmol/L has been shown to cause a -12.44mg/dL bias
    • Very dilute urine samples (specific gravity ≤1.010) may yield artificially high 24-hour Protein concentrations in large volume (>2500 mL) samples.
    • Very concentrated (specific gravity ≥1.025) urine samples may yield artificially low 24-hour protein concentrations in large volume (>2500 mL) samples.         
  • The following interpretive data is visible to practitioner: The following drugs will create a positive bias: Ceftriaxone, Deferoxamine mesylate.

Useful For

The filtration and resorption of plasma proteins in the formation of urine are important functions of the intact, healthy kidney. The presence of elevated concentrations of protein in urine (proteinuria) is a key finding in primary renal disease of glomerular, tubular, or mixed origin. Proteinuria is also seen in patients with systemic disorders that affect the kidneys such as diabetes mellitus, hypertension, vascular disease, neoplasia, drug toxicity, and certain infectious diseases. Proteinuria may also exist as either a benign or transient condition.