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HelpTest Code VANC Vancomycin Levels
Additional Codes
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Cerner |
NextGen |
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Vancomycin Level Trough |
Vancomycin Level Trough |
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Vancomycin Level Post Dose |
Vancomycin Level Post Dose |
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Vancomycin Level Random |
Vancomycin Level Random |
Methodology
(Vitros) Enzymatic Homogenous CIA, Two-point rate
Patient Preparation
None
Collection Instructions
- Standard phlebotomy practices.
- Collection Timing:
- Trough – 30 minutes prior to next dose or just before next dose
- Peak – first peak level 1 hour post infusion
Specimen Requirements
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Container |
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Stability |
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Rejection Criteria |
Gross Hemolysis |
Result Reporting and Reference Values
Reported in µg /mL.
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Low |
High |
Critical Low |
Critical High |
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Trough |
5 |
15 |
N/A |
30 |
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Peak |
20 |
40 |
N/A |
70 |
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Random |
10 |
30 |
N/A |
35 |
Reflex Testing
None
Limitations
- Ortho reports a bias with the following:
- Hemoglobin at 1000 mg/dL can cause a negative bias of 3.25 µg/mL
- Ortho reports no significant effect with the following:
- Bilirubin up to 60 mg/dL
- Lipemia up to 1000 mg/dL
Useful For
Vancomycin is used in the treatment of serious or severe infections caused by gram-positive organisms resistant to penicillins, cephalosporins, or other antimicrobial agents. It is also used in the treatment of antibiotic-associated pseudomembranous colitis produced by Clostridium difficile. The risk of ototoxicity and nephrotoxicity is increased in patients with impaired renal function, and in patients receiving concurrent aminoglycoside treatment. Serum or plasma vancomycin measurements are used in the diagnosis and treatment of vancomycin overdose and in monitoring levels to ensure appropriate therapy.