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HelpTest Code VALP Valproic Acid Level
Additional Codes
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Cerner |
NextGen |
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Valproic Acid Level |
Valproic Acid Level |
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Depakote Level |
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Alternate Name(s)
Valproate
Depakene
Depakote
Divalproex
Convulex
Methodology
(Vitros) Enzymatic Homogenous CIA, Two-point rate
Patient Preparation
None
Collection Instructions
- Standard phlebotomy practices.
- Collection Timing:
- The ideal specimen for monitoring blood concentration is that drawn just before the next dose, usually early in the morning, to confirm that an adequate dose has been prescribed before bedtime.
- Possible toxicity – at least 6 hours after the last dose
Specimen Requirements
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Container |
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Stability |
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Rejection Criteria |
Gross Hemolysis |
Result Reporting and Reference Values
Reported in µg /mL.
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Low |
High |
Critical Low |
Critical High |
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Therapeutic |
50 |
125 |
N/A |
>130 |
Reflex Testing
None
Limitations
- Ortho reports no significant effect with the following:
- Bilirubin of 60 mg/dL
- Hemoglobin of 1000 mg/dL
- Lipemia of 1000 mg/dL
Useful For
Valproic acid (Depakene or Depakote) is used as sole or adjunctive therapy in the treatment of simple and complex absence seizures, and adjunctively in patients with multiple seizure types, which include absence seizures. High concentrations of valproic acid may lead to central nervous system depression, tremor, and thrombocytopenia. Very high concentrations of valproic acid may also increase the risk of developing fatal hepatotoxicity, stupor, coma, or cerebral edema. Valproic acid is extensively metabolized by the liver. Serum or plasma valproic acid measurements are used in the diagnosis and treatment of valproic acid overdose and in monitoring levels to ensure appropriate therapy.