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HelpTest Code TIBC Iron And Total Iron Binding Capacity
Additional Codes
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Cerner |
NextGen |
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Iron And Total Iron Binding Capacity |
Iron And Total Iron Binding Capacity |
Alternate Name(s)
Total Iron Binding Capacity
TIBC
Iron Binding Capacity
IBC
Iron Saturation
Fe/TIBC
Methodology
- For Iron see: Iron Level - Fairbanks Memorial Hospital
- TIBC: Two-point rate
- Iron % Sat: Calculation
Patient Preparation
None
Collection Instructions
Standard phlebotomy practices.
Specimen Requirements
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Stability |
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Rejection Criteria |
Gross Hemolysis |
Result Reporting and Reference Values
- For Iron Level see: Iron Level - Fairbanks Memorial Hospital
- Total Iron Binding Capacity: reported in µg/dL.
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Low |
High |
Critical Low |
Critical High |
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0-30 day (male or female) |
60 |
175 |
N/A |
N/A |
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30 d – 150 y Male |
261 |
462 |
N/A |
N/A |
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30 d – 150 y Female |
265 |
497 |
N/A |
N/A |
- Iron % Sat:
- Female 15-50%
- Male 20-50%
Reflex Testing
None
Limitations
- Ortho reports a bias with the following:
- Desferal can cause a positive bias of 50%-80%
- Ferrous sulphate can cause a negatie bias of 8%-18%
- Ortho reports no significant effect with the following:
- Bilirubin up to 27 g/dL
- Hemoglobin up to 1000 mg/dL
- Lipemia up to 800 mg/dL
- The following interpretive data is visible to practitioner: Patients on Desferal show significant positive interference, samples containing ferrous sulfate give results with a negative bias.
Useful For
The measurements of serum iron and serum iron-binding capacity are useful in the differential diagnosis of anemia, iron deficiency anemia, thalassemia, possible sideroblastic anemia, and iron poisoning. Total iron-binding capacity (TIBC) in serum, representing the iron-binding capacity of transferrin, is a useful index of nutritional status. Serum TIBC varies in disorders of iron metabolism. Serum TIBC is increased in iron deficiency and decreased in chronic inflammatory disorders, malignancies and hemochromatosis.