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Test Code PROG Progesterone

Additional Codes

Cerner

NextGen

Progesterone

Progesterone

Methodology

Chemiluminescent Competitive Immunoassay

Patient Preparation

None

Collection Instructions

Standard phlebotomy practices.

Specimen Requirements

Container

Specimen Type

Tube

Lithium Heparin Plasma

PST

 or  or 

Serum

 or 

SST

 or  or 

 

Stability

Storage

Temperature

Stability

Room Temperature

18-28°C

Not recommended

Refrigerated

 2-8°C

≤ 7 days

Frozen

≤-20 °C

4 weeks

Thaw 1 time only

Rejection Criteria

Gross Hemolysis

Turbid Specimens

Result Reporting and Reference Values

Reported in ng/mL

Ovulatory Cycle:

 

 

Normal Female follicular phase

 

2.61

Normal Female Periovulatory phase

 

5.86

Normal Female mid-luteal phase

6.82

27.90

Normal Female luteal phase

1.30

22.20

 

 

 

Post Menopausal Female

 

0.52

 

 

 

Pregnant Females:

 

 

1st Trimester (4-12 weeks gestation)

3.85

35.70

2nd Trimester (13-24 weeks gestation)

15.3

 

3rd Trimester (24-36 weeks gestation)

39.8

 

 

 

 

Normal Male

 

 0.79

Reflex Testing

None

Limitations

  • Ortho reports a bias with the following:
    • High Cholesterol can cause a negative bias
    • High Lipids can cause a negative bias
    • Low Protein can cause a negative bias
  • Ortho reports no significant effect with the following:
    • Bilirubin up to 40 mg/dL
    • Hemoglobin up to 1000 mg/dL

Useful For

The main sites of progesterone production are the adrenal cortex, ovaries, and corpus luteum following ovulation and the placenta by the twelfth week of pregnancy. Circulating progesterone is bound to several serum proteins including albumin and corticosteroid binding globulin. Measurement of serum progesterone is useful in the investigation of ovarian function where disorders of ovulation are responsible for infertility in 15-20% of patients, and for predicting ovulation in induced cycles, where concentrations are generally higher than normal. Corpus luteum dysfunction is indicated by lower than normal progesterone concentrations.