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Test Code FT4 Free T4

Additional Codes

Cerner

NextGen

T4 Free

T4 Free

Alternate Name(s)

Free T4

FT4

Free thyroxine

Methodology

(Vitros) Immunometric immunoassay, Chemiluminescent

Patient Preparation

None

Collection Instructions

Standard phlebotomy practices.

Specimen Requirements

Container

Specimen Type

Tube

Serum

 or 

SST

 or  or 

 

Stability

Storage

Temperature

Stability

Room Temperature

18-28°C

Not recommended

Refrigerated

 2-8°C

≤ 7 days

Frozen

≤-20 °C

4 weeks

Thaw 1 time only

Rejection Criteria

Gross Hemolysis

Turbid Specimens

Result Reporting and Reference Values

Reported in ng/dL

Age

Low

High

0-3 Days

2.0

5.0

4days-30 days

0.9

2.2

31 days-18Y

0.8

2.0

18 – 150Y

0.78

2.19

Reflex Testing

None

Limitations

The following interpretive data is visible to practitioner: Mefanamic acid, Sodium salicylate, o-Acetylsalicyclic acid (Aspirin), Phenytoin of 10 mg/dL, Bilirubin of 20 mg/dL and Diclofenac could create a significant positive bias.

Useful For

The free fraction of the circulating thyroxine (T4) is considered to exert the main influence on metabolic control.  Consequently, the FT4 concentration is believed to be the most direct indicator of an individual’s thyroid status.  FT4 concentrations are generally depressed in hypothyroidism and raised in hyperthyroidism.  Measurement of FT4 thus provides an aid to the differential diagnosis of thyroid disease.