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Test Code FOPIA Opiates, Serum or Plasma, Quantitative

Method Name

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Reporting Name

Opiates, Serum or Plasma, Quant.

Specimen Type

Varies


Specimen Required


Submit only one of the following specimens:

 

Plasma

Specimen Type: Plasma

Container/Tube: Gray top (potassium oxalate/sodium fluoride), Green top (sodium heparin), Lavender top (EDTA), or pink top (K2EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Draw blood in a gray top (potassium oxalate/sodium fluoride), green (sodium heparin), lavender (EDTA) or pink (K2EDTA) tube(s). Spin down and send 1 mL of plasma refrigerated in a plastic vial.

 

Note: Label specimen appropriately (plasma).

 

Serum

Specimen Type: Serum

Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Draw blood in a plain, red-top tube(s). Spin down and send 1 mL of serum refrigerated in a plastic vial.

 

Note: Label specimen appropriately (serum).


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Refrigerated (preferred) 14 days
  Ambient  7 days
  Frozen 

Reject Due To

Hemolysis Mild Reject; Gross Reject
Lipemia Mild OK; Gross OK
Other Separator tubes, Plasma or Whole blood collected in light blue (sodium citrate), specimens exposed to repeat freeze/thaw cycles.

Reference Values

Drugs covered: codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone. All drugs covered and the non-glucuronidated (free) form.

 

Positive cutoff: 2 ng/mL

 

For medical purposes only; not valid for forensic use.

 

Interpretation

Identification of specific drug(s) taken by specimen donor is problematic due to common metabolites, some of which are prescription drugs themselves. The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, or limitations of testing. All drugs covered are the nonglucuronidated (free) form. The concentration value must be greater than or equal to the cutoff to be reported as positive.  A very small amount of an unexpected drug analyte in the presence of a large amount of an expected drug analyte may reflect pharmaceutical impurity. Interpretive questions should be directed to the laboratory.

Day(s) Performed

Monday, Wednesday and Friday

Report Available

3-11 days

Performing Laboratory

ARUP Laboratories

CPT Code Information

80361, 80365

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FOPIA Opiates, Serum or Plasma, Quant. 8217-2

 

Result ID Test Result Name Result LOINC Value
Z4427 6-acetylmorphine, S/P, Quant 12788-6
Z4428 Codeine, S/P, Quant 3506-3
Z4429 Morphine, S/P, Quant 3827-3
Z4430 Hydrocodone, S/P, Quant 3680-6
Z4431 Hydromorphone, S/P, Quant 3683-0
Z4432 Oxycodone, S/P, Quant 3893-5
Z4433 Oxymorphone, S/P, Quant 60467-8

Test Classification

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.