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Test Code FIAAB IA2 Autoantibodies


Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Centrifuge and aliquot 1 mL of serum into a plastic vial.

2. Freeze immediately after separation and send frozen.


Secondary ID

75936

Method Name

Enzyme-linked Immunosorbent Assay (ELISA)

Reporting Name

IA-2 Autoantibodies

Specimen Type

Serum

Specimen Minimum Volume

0.5 mL (Note: Minimum volume does not allow for repeat analysis)

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 107 days
  Ambient  72 hours
  Refrigerated  72 hours

Clinical Information

Type 1 diabetes, commonly referred to as insulin-dependent diabetes mellitus (IDDM), is caused by pancreatic beta-cell destruction that leads to an absolute insulin deficiency.(1) The clinical onset of diabetes does not occur until 80% to 90% of these cells have been destroyed. Prior to clinical onset, type 1 diabetes is often characterized by circulating autoantibodies against a variety of islet cell antigens, including glutamic acid decarboxylase (GAD), tyrosine phosphatase (IA2), and insulin.(2-7) The autoimmune destruction of the insulin-producing pancreatic beta cells is thought to be the primary cause of type 1 diabetes. The presence of these autoantibodies provides early evidence of autoimmune disease activity, and their measurement can be useful in assisting the physician with the prediction, diagnosis, and management of patients with diabetes. Autoantibodies to IA2, a tyrosine phosphatase-like protein, are found in 50% to 75% of type 1 diabetics at and prior to disease onset. These autoantibodies are generally more prevalent in younger onset patients. Because the risk of diabetes is increased with the presence of each additional autoantibody, the positive predictive value of the IA2 antibody test is enhanced when measured in conjunction with antibodies to GAD and insulin.

Reference Values

Negative: <7.5

Positive: ≥ 7.5

Day(s) Performed

Varies

Report Available

7 to 14 days

Performing Laboratory

Esoterix Endocrinology

CPT Code Information

86341

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FIAAB IA-2 Autoantibodies 31209-0

 

Result ID Test Result Name Result LOINC Value
FIAAB IA-2 Autoantibodies 31209-0