Useful For

Estradiol is produced by the adrenals, placenta, and testes and is the principal estrogen secreted by the ovaries.  Estradiol normally exerts negative feedback control on gonadotropin release, however, as estradiol production accelerates with the rapid growth of the dominant follicle, this feedback becomes positive, causing a surge in LH secretion, and ovulation occurs.  The measurement of estradiol is useful in assessing a variety of menstrual dysfunctions including delayed puberty, amenorrhea, and menopause.